Rugani has his name taken for the foul, which is likely to be the final action of the game.
SAVE! Szczesny dives the right way to prevent a last-gasp goal for Valencia, which would have only been a consolation, and preserves his clean sheet.
The attempt from Parejo was poor and sums up what is a disappointing return to the Champions League from Valencia.
90' +5
The frustrating thing for Valencia is that both goals came from poor defensive mistakes and they have done well to restrict the chances Juventus have created from open play.
PENALTY! Rugani is penalised for a challenge on Gabriel as he headed the ball away and the referee points to the spot again. It is a very soft decision.
90' +3
Rodrigo rises to head an attempt on goal but he mistimes his jump and cannot get enough on the ball to test Szczesny.
90' +1
The fourth official has signalled six minutes of additional time.
90'
SAVE! Wass drills a low ball into the area where Moreno tries to stab home but Szczesny is equal to the effort.
89'
D. Rugani enters the game and replaces Douglas Costa.
Costa, himself a substitute, is forced off with an injury and is replaced by Rugani.
86'
SAVE! Juventus get a rare chance on the break and Costa forces a save from Neto but he appears to have hurt himself after Gabriel's sliding challenge.
85'
Even Mandzukic has switched to a more defensive role, as Juventus look to defend their advantage.
83'
Juventus are riding their luck defensively at the moment as Valencia continue to bang on the door but the hosts have not brought their shooting boots, as their tally of shots off target reaches double figures.
Minute
Description
81'
W. Szczęsny gets yellow.
Szczesny has his name taken by the referee for time wasting, as we edge towards the closing stages in the Mestella.
80'
Cheryshev stretches the Juventus defence with a surging run down the left but Valencia are crowded out when they try to shift the ball into a central area.
79'
Another effort from range from Soler, another comfortable save for Szczesny. Valencia are running out of ideas and time is also against them.
77'
A succession of corners comes to a close with an offside flag, as Valencia make a mistake and waste a glorious opportunity.
76'
For all of Valencia's possession, they still do not look like they will find a goal but they do earn a corner as Gaya's cross is deflected behind. It is taken short before being floated into the middle, where it is headed behind for another corner.
74'
Juventus are running down the clock as they knock the ball around the defence but Valencia soon have possession and will push forward once again.
72'
Soler has another shot from the edge of the box but he does not strike it cleanly, giving Szczesny another easy save.
70'
Santi Mina enters the game and replaces Gonçalo Guedes.
K. Gameiro enters the game and replaces M. Batshuayi.
Double change for Valencia, the first of which sees Gameiro replace Batshuayi.
The other change sees Guedes, who looked bright in the first period but struggled to replicate that after the break, replaced by Mina.
69'
Valencia continue to move the ball around well but they are unable to carve their way through the Juventus defence, who continue to stand firm.
67'
Douglas Costa enters the game and replaces M. Pjanić.
There will be no hat-trick for Pjanic, as he makes way for the introduction of Costa.
66'
The resulting corner comes to nothing, as Batshuayi is flagged offside.
65'
SAVE! Valencia finally ask questions of Szczesny as Soler, who has come to life in the second half, tries to curl towards the far corner but has his effort tipped behind by the Juventus stopper.
64'
Down to ten men and holding a 2-0 lead, Juventus are showing no desire to extend their advantage and are focusing on quelling any threat of Valencia clawing their way back into the game.
62'
Valencia have certainly improved in the past five minutes or so but, for all their hard work, Szczesny is still finding things very easy between the posts.
60'
The resulting free-kick comes to nothing but Juventus have taken their foot off the gas, so Valencia will come right back at them.
59'
Alex Sandro gets yellow.
Sandro is penalised for what appeared to be a soft foul on Rodrigo and is shown a yellow card.
58'
WIDE! Valencia knock the ball around patiently before Soler strikes an effort from outside the box but he fails to hit the target.
57'
D. Cheryshev enters the game and replaces Rúben Vezo.
Tactical change for Valencia, as full-back Vezo is replaced by Russia's World Cup hero Cheryshev.
56'
Juventus may be down to ten men but it is Valencia who appear to have lost their discipline. The two penalties are testament to that and there is a risk that things could only get worse for the hosts.
54'
Rúben Vezo gets yellow.
Vezo becomes the third Valencia player to be booked following a foul on Matuidi.
53'
A huge blow for Valencia to concede so soon after the break but Murillo can have no complaints. It was poor defending to allow Bonucci to get past him and he committed a blatant foul.
51'
Penalty goal scored by M. Pjanić for Juventus!
GOAL! 2-0 Juventus! Pjanic again gets the better of Neto from the penalty spot as he goes the same way and tucks his effort into the corner.
50'
PENALTY! Juventus get their second penalty of the night! Murillo is all over the back of Bonucci and hauls him to ground, giving the referee a very easy decision to make.
49'
J. Murillo gets yellow.
Juventus immediately looking to cause problems at the other end, as the visitors earn a corner.
Murillo is the player penalised and earns himself a deserved yellow card.
47'
SAVE! Guedes plays a neat reverse pass to Gaya, who crosses into the middle where Rodrigo can only head straight at Szczesny.
46'
We are back underway at the Mestella, where Valencia restart the action.
45' +3
HALF TIME! VALENCIA 0-1 JUVENTUS
45' +2
Valencia putting Juventus under pressure as we edge towards the interval but they are still unable to carve a way through Juventus' defence.
45'
Penalty goal scored by M. Pjanić for Juventus!
GOAL! 1-0 Juventus! Pjanic cooly slots the ball into the bottom right-hand corner, just beyond the reach of Neto to give the visitors a narrow advantage.
43'
Dani Parejo gets yellow.
Parejo is booked for his challenge on Cancelo that conceded the penalty.
PENALTY! A high foot from Parejo on the rebound sees Juventus given a golden opportunity to take the lead. It is a very poor challenge from the Valencia man.
OFF THE BAR! Cancelo inches away from opening the scoring against his former side but his effort receives a crucial touch from Neto.
42'
Juventus, unsurprisingly, have had the wind taken out of their sails since Ronaldo's dismissal. The interval will be crucial for both teams.
38'
SAVE! Batshuayi brilliantly turns his marker inside the area and smashes an attempt towards the near post but it is straight at Szczesny.
37'
Valencia trying to work their way through the gears and Guedes is looking lively down the left, although Rodrigo in the middle has seen very little of the ball.
35'
The incident has certainly providing a spark to the match and the home fans in the Mestella, who jeered Ronaldo at the start of the game, have increased the noise levels to encourage their team.
33'
Juventus now have a much more difficult task on their hands and there is a risk that UEFA judges the action to have been violent, which could mean a three-match suspension.
31'
A very controversial moment and the red card, from the angles we have seen, looks harsh. Murillo was looking for a reaction and has got exactly what he wanted.
29'
Cristiano Ronaldo goes off after a red card!
RED CARD! Ronaldo is sent off! An off the ball incident with Murillo leaves Ronaldo the Juventus man frustrated and he appears to pull the hair of the defender. His night comes to a premature end and he leaves the field in tears.
27'
A better spell on the ball for Valencia now but Szczesny has had a very easy game so far, as he is yet to be tested.
25'
After looking threatening in the early stages, Valencia are now struggling to get the ball out of their own half and the tempo of the game has shifted in Juventus' favour.
23'
E. Can enters the game and replaces S. Khedira.
Juventus suffer a midfield blow as Khedira is forced off with what appears to be a hamstring injury and Can introduced in his place.
21'
HUGE CHANCE! Scramble inside the Valencia box as Juventus threaten once again, with Bernardeschi seeing his attempt saved by Neto before Matuidi's rebound was crucially blocked by Murillo.
20'
Valencia earn a chance to threaten in attack following a corner but Juventus' experienced defence stands firm.
19'
Juventus have now had two very good opportunities that have started down the left side but they could live to rue those missed chances.
17'
WHAT A MISS! Ronaldo plays an inviting cross to Bernardeschi at the far post, who taps the ball back across goal but Khedira strikes over the bar.
15'
Juventus are starting to grow into the game and have put Valencia on the back foot in the past few minutes, although Neto is yet to be tested.
13'
Valencia will be very pleased with how they have performed so far and they have impressed in their return to Champions League action. There is still a long way to go though.
11'
OVER! Big chance for Juventus as Bernardeschi's cross towards the far post is bounced back across goal by Ronaldo and Mandzukic tries to smash home with a first-time effort but his the ball over the bar.
10'
Ronaldo strikes at goal but does not hit it cleanly, although he does win a corner. Bernardeschi's delivery is dealt with though and Juventus have to start again from the back.
8'
Ronaldo pushing forward for the first time down the left to earn a free-kick, which is taken short before being curled into the middle. Valencia manage to quell the danger though.
6'
Juventus have seen very little of the ball so far but have a defensive free-kick after Soler trips Sandro.
4'
Juventus head the corner away but Valencia are straight back on the front foot.
3'
A bright start for Valencia, who have seen plenty of the ball in the opening minutes, as Guedes' shot from distance is deflected behind for a corner.
1'
We are underway at the Mestella, where Juventus start with the ball.
Hello and welcome to our LIVE coverage of the Champions League clash between Valencia and Juventus, as the two sides begin their campaign in the competition.
Valencia are back amongst the continent's elite for the first time since 2015 and will hope to advance past the group stages, having last made it through to the knockout rounds in the 2012-13 season. However, they have a stern against one of Europe's finest in their first game back.
Juventus, beaten finalists in two of the last four seasons, are amongst the favourites to go all the way this season and their side has been boosted significantly by the capture of a certain Cristiano Ronaldo. He opened his account for the Italian side at the weekend, providing a huge confidence boost for this match.
Valencia XI (4-4-2): Neto; Ruben Vezo, Gabriel, Jeison Murillo, Jose Gaya; Carlos Soler, Daniel Parejo, Daniel Wass, Goncalo Guedes; Rodrigo Moreno, Michy Batshuayi.
Juventus XI (4-3-3): Wojciech Szczesny; Joao Cancelo, Leonardo Bonucci, Georgio Chiellini, Alex Sandro; Sami Khedira, Miralem Pjanic, Blaise Matuidi; Federico Bernardeschi, Mario Mandzukic, Cristiano Ronaldo.
Juventus subs: Mattia Perin, Medhi Benatia, Emre Can, Daniele Rugani, Juan Cuadrado, Douglas Costa, Paulo Dybala.
Marcelino makes six changes to the side that drew 0-0 with Real Betis at the weekend, bringing in Neto, Vezo, Murillo, Guedes, Wass, Soler and Batshuayi. Domenech, Piccini, Diakhaby, Cheryshev and Torres drop to the bench, while Geoffrey Kondogbia misses out through injury.
Massimiliano Allegri has made three changes from the Juventus side that defeated Sassuolo at the weekend as Chiellini, Pjanic and Bernardeschi are drafted in. As a result, Benatia, Can and Dybala drop to the bench, where they are joined by Douglas Costa who was sent off for spitting in the last match.
The two teams are on the field as the famous Champions League anthem blasts from the speakers, signalling just a few minutes until the action begins.
A dramatic first half in the Mestella, where the headlines will be taken by Ronaldo but for all the wrong reasons. His red card looked to be harsh but Juventus have responded in his absence as Pjanic tucked home from the spot.
Juventus will need to keep their heads in the second half to ensure they do not risk further action from the officials. Valencia, meanwhile, must put the visiting defence under more pressure as they have not asked enough of Szczesny between the sticks.
Juventus emerge victors on a dramatic night in the Mestella, where two penalties from Pjanic handed all three points to Allegri's side. All the post-game talk will surround Cristiano Ronaldo's first-half dismissal though, while Valencia will need to improve on their attacking performance and must also be more disciplined defensively.
Thanks for joining our coverage today. Until next time, goodbye.
Allegri's side will now look ahead to their next clash against Young Boys, where they will be expected to win despite likely being without Ronaldo. Meanwhile, Valencia have a huge task on their hands as they travel to Old Trafford to face Manchester United.
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